Publicações relacionadas à zika
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In:
Australian and New Zealand Journal of Public Health
Authors:
José G. Derraik, David Slaney
There has never been a confirmed indigenously acquired case of mosquito-borne disease in humans in New Zealand.1 It has been proposed that it is just a matter of time before such an outbreak occurs,2 particularly in light of the increased connectivity and movement of people and pathogens around the globe.
In the past few years, the emergence of Chikungunya virus is posing a threat to public health in NZ.3 This risk has increased with the Chikungunya outbreaks in New Caledonia and Papua New Guinea,4 and more recently in Tonga,5 Samoa, American Samoa,6 French Polynesia,7 and Tokelau Islands (a NZ territory).8 Recent outbreaks of Zika virus disease (family Flaviviridae, genus Flavivirus) in the South Pacific9,10 and associated imported cases to NZ raise concerns about the likelihood of this virus reaching NZ.
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In:
American Journal of Medical Genetics
Authors:
Diana Alcantara and Mark O'driscoll
The underlying etiologies of genetic congenital microcephaly are complex and multifactorial. Recently, with the exponential growth in the identification and characterization of novel genetic causes of congenital microcephaly, there has been a consolidation and emergence of certain themes concerning underlying pathomechanisms. These include abnormal mitotic microtubule spindle structure, numerical and structural abnormalities of the centrosome, altered cilia function, impaired DNA repair, DNA Damage Response signaling and DNA replication, along with attenuated cell cycle checkpoint proficiency. Many of these processes are highly interconnected. Interestingly, a defect in a gene whose encoded protein has a canonical function in one of these processes can often have multiple impacts at the cellular level involving several of these pathways. Here, we overview the key pathomechanistic themes underlying profound congenital microcephaly, and emphasize their interconnected nature.
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In:
Microbes and Infection
Authors:
Leticia A.M. Carneiro, Leonardo H. Travassos
Abstract:
Despite a long battle that was started by Oswaldo Cruz more than a century ago, in 1903, Brazil still struggles to fight Aedes aegypti and 88 Aedes albopictus, the mosquito vectors of dengue virus (DENV), Chikungynya virus (CHIKV) and Zika virus (ZIKV). Dengue fever has 89 been a serious public health problem in Brazil for decades, with recurrent epidemic outbreaks occurring during summers. In 2015, until 90 November, 1,534,932 possible cases were reported to the Ministry of Healthv. More recently, the less studied CHIKV and ZIKV 91 have gained attention because of a dramatic increase in their incidence (around 400% for CHIKV) and the association of ZIKV infection with 92 a 11-fold increase in the number of cases of microcephaly from 2014 to 2015 in northeast Brazil (1761 cases until December 2015). The symptoms of these three infections are very similar, which complicates the diagnosis. These include fever, headache, nausea, fatigue, 95 and joint pain. In some cases, DENV infection develops into dengue hemorrhagic fever, a life threatening condition characterized by 96 bleeding and decreases in platelet numbers in the blood. As for CHIKV, the most important complication is joint pain, which can last for 97 months.
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In:
Bulletin de la Société de Pathologie Exotique
Authors:
C. Chastel
Au cours des deux dernières décennies, on a assisté à l’émergence brutale d’un certain nombre de flavivirus transmis par des moustiques, principalement d’origine africaine, envahissant des régions géographiques où ils n’avaient jamais été actifs. Ce fut le cas pour le virus de l’encéphalite japonaise (JEV) qui, à partir de 1995, a gagné le Nord-Est de l’Australie et, surtout, du virus West Nile (WNV) qui a colonisé tout le continent américain à partir de 1999. Puis, dès 2001, le virus Usutu (USUV) a infecté une grande partie de l’Europe occidentale et le virus Zika (ZIKV) a provoqué une sérieuse épidémie en Micronésie (2007). Enfin, en 2010, le virus Tembusu (TMUV) a ravagé des élevages de canards en Chine, tandis que le virus Bagaza, après s’être manifesté au Kerala, en Inde, par des cas d’encéphalites humaines, a infecté le Sud de l’Espagne. Des pouvoirs pathogènes nouveaux ont été observés chez l’Homme et chez l’animal, en même temps que des voies inhabituelles de contamination étaient décrites et que ces virus infectaient des hôtes vertébrés nouveaux et de nouvelles espèces de moustiques. Les causes de cette évolution inattendue restent obscures.
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In:
Emerging Infectious Diseases
Authors:
Cristiane W. Cardoso, Igor A.D. Paploski, Mariana Kikuti, Moreno S. Rodrigues, Monaise M.O. Silva, Gubio S. Campos, Silvia I. Sardi, Uriel Kitron, Mitermayer G. Reis, Guilherme S. Ribeiro
Zika virus (ZIKV) has been recognized as an emerging mosquito-borne flavivirus since outbreaks were reported from Yap Island in 2007, French Polynesia in 2013, and Cook Island and New Caledonia in 2014. It has joined dengue virus (DENV) and chikungunya virus (CHIKV) as global public health threats. ZIKV infection typically causes a self-limited dengue-like illness characterized by exanthema, low-grade fever, conjunctivitis, and arthralgia, and an increase in rates of Guillain-Barré syndrome have been observed during ZIKV outbreaks.
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