Publicações relacionadas à zika
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In:
Proceeding of the National Academy of Sciences of the United States of America (PNAS)
Authors:
Megan A. Sheridan, Dinar Yunusov, Velmurugan Balaraman, Andrei P. Alexenkoa, Shinichiro Yabe, Sergio Verjovski-Almeida, Danny J. Schust, Alexander Franz, Yoel Sadovskyh, Toshihiko Ezashi and R. Michael Roberts
Significance
We have tested the hypothesis that the placenta of early pregnancy might be more easily breached by the Zika virus (ZIKV) than the relatively resistant outer cells of the mature placenta. Colonies of placental lineage cells derived from embryonic stem cells, which are probably analogous to the primitive placenta at implantation, were lysed more rapidly by an African strain of ZIKV, considered relatively benign, than by an Asian strain linked to fetal brain abnormalities. We conclude that the human fetus may be most vulnerable to ZIKV very early in pregnancy and that the African strain may threaten a pregnancy more strongly than previously believed.
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In:
Emerging Infectious Diseases
Authors:
Sara Lammert, Allison Taylor Walker, Stefanie Erskine, Sowmya R. Rao, Douglas H. Esposito, Edward T. Ryan, Gregory K. Robbins, Regina C. LaRocque
Zika virus has recently been introduced to the Americas and is spreading rapidly. We evaluated the characteristics of US travelers to Zika virus–affected countries who were seen at Global TravEpiNet sites during March 2015–October 2016. Nearly three quarters of travelers were men or women of reproductive age.
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In:
Nature
Authors:
Patricia P. Garcez, Juliana Minardi Nascimento, Janaina Mota de Vasconcelos, Rodrigo Madeiro da Costa, Rodrigo Delvecchio, Pablo Trindade, Erick Correia Loiola, Luiza M. Higa, Juliana S. Cassoli, Gabriela Vitória, Patricia C. Sequeira, Jaroslaw Sochacki, Renato S. Aguiar, Hellen Thais Fuzii, Ana M. Bispo de Filippis, João Lídio da Silva Gonçalves Vianez Júnior, Amilcar Tanuri, Daniel Martins-de-Souza & Stevens K. Rehen
Abstract
Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is circulating in Brazil. Combining proteomics and mRNA transcriptional profiling, over 500 proteins and genes associated with the Brazilian ZIKV infection were found to be differentially expressed. These genes and proteins provide an interactome map, which indicates that ZIKV controls the expression of RNA processing bodies, miRNA biogenesis and splicing factors required for self-replication. It also suggests that impairments in the molecular pathways underpinning cell cycle and neuronal differentiation are caused by ZIKV. These results point to biological mechanisms implicated in brain malformations, which are important to further the understanding of ZIKV infection and can be exploited as therapeutic potential targets to mitigate it.
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In:
Emerging Infectious Diseases
Authors:
Veasna Duong, Sivuth Ong, Rithea Leang, Rekol Huy, Sowath Ly, Ugo Mounier, Teyputita Ou, Saraden In, Borin Peng, Sreymom Ken, Philippe Buchy, Arnaud Tarantola, Paul F. Horwood, and Philippe Dussart
We describe a retrospective study on circulation of Zika virus in Cambodia during 2007–2016 among patients with dengue-like symptoms and Aedes aegypti mosquitoes. Our findings suggest that Zika virus in Cambodia belongs to the Asia genotype, is endemic, has low prevalence, and has had low-level impact on public health.
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In:
American Journal of Obstetrics & Gynecology
Authors:
Kjersti Aagaard, Melissa Suter, Maxim Seferovic, Min Hu, Maike Kahr, Catherine Eppes, Martha Rac, Michael Belfort
OBJECTIVE: Zika virus (ZIKV) is an emerging mosquito-borne flavivirus. A causal link explaining the delay between maternal symptoms and fetal infection is missing, and why prior African outbreaks were not associated with fetal malformations is unknown. In this study, we sought to answer these questions using state-of-the-science approaches with a single passage contemporary
ZIKV strain and infection of high purity trophoblasts from uninfected donors.
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