In:

Journal of Clinical Virology

Authors:

Guilherme A. Calveta, Ana Maria B. Filippis, Marcos Cesar L. Mendonc,Patricia C. Sequeira, Andre M. Siqueira, Valdilea G. Veloso, Rita M. Nogueira,Patrícia Brasil

Abstract

Since May 2015, Brazil’s Ministry of Health has reported autochthonous transmission of Zika virus (ZIKV)in some states of the country. Simultaneous circulation of Dengue, Chikungunya and ZIKV in the coun-try hinder both the diagnosis and the therapeutic approach of patients seeking care with acute febrileillnesses especially in patients with comorbidities. The association between HIV infection and endemicdiseases has been described especially in tropical regions with varying levels of complications, althoughthere has been no report of ZIKV in HIV-infected patients. We report the first autochthonous case oflaboratory confirmed ZIKV infection in a HIV-infected patient in Rio de Janeiro, Brazil. He evolved withonly mild symptoms and recovered well without major laboratory abnormalities. Phylogenetic analysisof the ZIKV detected in the patient sera clustered within the Asian clade. To the best of our knowledge,this is the first time that Zika virus co-infection is reported in a HIV-infected patient.

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