Publicações relacionadas à zika
- Details
In:
The New England Journal of Medicine
Authors:
R.W. Driggers, C.-Y. Ho, E.M. Korhonen, S. Kuivanen, A.J. Jääskeläinen, T. Smura, A. Rosenberg, D.A. Hill, R.L. DeBiasi, G. Vezina, J. Timofeev, F.J. Rodriguez, L. Levanov, J. Razak, P. Iyengar, A. Hennenfent, R. Kennedy, R. Lanciotti, A. du Plessis, and O. Vapalahti
Summary
The current outbreak of Zika virus (ZIKV) infection has been associated with an apparent increased risk of congenital microcephaly. We describe a case of a preg- nant woman and her fetus infected with ZIKV during the 11th gestational week. The fetal head circumference decreased from the 47th percentile to the 24th per- centile between 16 and 20 weeks of gestation. ZIKV RNA was identified in mater- nal serum at 16 and 21 weeks of gestation. At 19 and 20 weeks of gestation, substantial brain abnormalities were detected on ultrasonography and magnetic resonance imaging (MRI) without the presence of microcephaly or intracranial calcifications. On postmortem analysis of the fetal brain, diffuse cerebral cortical thinning, high ZIKV RNA loads, and viral particles were detected, and ZIKV was subsequently isolated.
Download full publication:
- Details
In:
The Lancet
Authors:
Jean Michel Mansuy, Marine Dutertre, Catherine Mengelle, Camille Fourcade, Bruno Marchou, Pierre Delobel, Jacques Izopet,
Guillaume Martin-Blondel
The recent, rapid spread of Zika virus in South America and increasing reports of cases of congenital abnormalities spatiotemporally associated with Zika virus infections led WHO to declare a Public Health Emergency of International Concern on Feb 1. WHO also recently described measures that pregnant women should take to avoid infection.
Download full publication:
- Details
In:
The Lancet
Authors:
Didier Musso, David Baud
Until the French Polynesian outbreak in 2013–14, Zika virus disease was thought to be only a mild disease. During this outbreak, the incidence of Guillain-Barré syndrome was 20 times higher than expected.1 Similarly, the emergence of Zika virus in the Americas since 2015 has been associated with a dramatic increase of reported cases of microcephaly.2 As for Zika virus and Guillain-Barré syndrome in French Polynesia, the temporal association between Zika virus outbreaks and microcephaly in Brazil strongly suggests that Zika virus infection during pregnancy might cause severe neurological damage in neonates. The challenge now is to provide empirical evidence for the link between Zika virus and microcephaly, and the demonstration that Zika virus can cross the placental barrier and infect the neonate strongly favours this association.
Download full publication:
- Details
In:
Journal of Clinical Microbiology
Authors:
Jesse J. Waggoner a and Benjamin A. Pinsky
Abstract
Zika virus (ZIKV) is an Aedes mosquito-borne flavivirus that emerged in Brazil in 2015 and then rapidly spread throughout the tropical and subtropical Americas. Based on clinical criteria alone, ZIKV cannot be reliably distinguished from infections with other pathogens that cause an undifferentiated systemic febrile illness, including infections with two common arboviruses, dengue virus and chikungunya virus. This review details the methods that are available to diagnose ZIKV infection.
Download full publication:
- Details
In:
International Journal of Clinical Practice
Author:
R. A. Stein
Particularly over the past few decades, emerging and re-emerging infectious diseases have provided insights into the dynamic complexity of the host–pathogen interface. By late 2012, at least 219 human viral species were recognised, and three to four new human viruses are discovered annually (1). Most known and emerging human viruses are zoonoses (2,3). The natural reservoirs of zoonotic pathogens often remain elusive, despite extensive research efforts that sometimes span decades. For example, even though the first human Ebola virus outbreaks were reported in 1976 (4,5), direct evidence that bats might be the natural reservoir came only in 2005 (6), and the virus itself has still not been isolated from bats (7–9).
Download full publication: