Publicações relacionadas à zika
- Details
In:
The New England Journal of Medicine
Authors:
Eric J. Rubin, M.D., Ph.D., Michael F. Greene, M.D., and Lindsey R. Baden, M.D.
Zika virus has been sweeping through South and Central America, with more than a million suspected cases during the past few months, along with a substantial increase in reporting of infants born with microcephaly.1,2 Thus far, the two outbreaks have largely been epidemiologically associated in time and geography. However, Mlakar and colleagues3 now report in the Journal molecular genetic and electron-microscopic data from a case that helps to strengthen the biologic association.
Download full publication:
- Details
In:
The Lancet
Authors:
Mauricio L Barreto, Manoel Barral-Netto, Rodrigo Stabeli, Naomar Almeida-Filho, Pedro F C Vasconcelos, Mauro Teixeira, Paulo Buss, Paulo E Gadelha
Since 1981, the Brazilian population has had dengue fever epidemics and all control eff orts have been unsuccessful.1 In 2014, chikungunya fever was reported for the fi rst time in the country.2 In 2015, the occurrence of Zika virus was also reported,3 along with an increase of microcephaly and brain damage in newborn babies.4,5 The mosquito Aedes aegypti is the most conventional vector of these three viral infections and is widely disseminated in a great part of urban Brazil. Brazilian public health authorities declared a National Public Health Emergency on Nov 11, 2015, and intensifi ed the vector control campaign to tackle the epidemic.6 A few months later, on Feb 1, 2016, in view of the spread of the Zika virus in several Latin American and Caribbean countries, the report of cases in North American and European citizens upon return from those countries, and concerns about reported clusters of microcephaly and other neurological disorders, WHO declared a Public Health Emergency of International Concern.7
Download full publication:
- Details
In:
Journal of Infection
Authors:
Jasper F.W. Chan, Garnet K.Y. Choi, Cyril C.Y. Yip, Vincent C.C. Cheng, Kwok-Yung Yuen
Summary
Unlike its mosquito-borne relatives which can cause severe human diseases, including dengue, West Nile, and Japanese encephalitis viruses, Zika virus (ZIKV) has emerged from obscurity by its association with a suspected “congenital Zika syndrome”, while causing asymptomatic or mild exanthematous febrile infections which are dengue- or rubella-like in infected individuals. Despite having been discovered in Uganda for almost 60 years, <20 human cases were reported before 2007. The massive epidemics in the Pacific islands associated with the ZIKV Asian lineage in 2007 and 2013 were followed by explosive outbreaks in Latin America in 2015. Although increased mosquito breeding associated with the El Niño effect superimposed on global warming is suspected, genetic changes in its RNA virus genome may have led to better adaptation to mosquitoes, other animal reservoirs, and human. We reviewed the epidemiology, clinical manifestation, virology, pathogenesis, laboratory diagnosis, management, and prevention of this emerging infection. Laboratory diagnosis can be confounded by cross-reactivity with other circulating flaviviruses. Besides mosquito bite and transplacental transmission, the risk of other potential routes of transmission by transfusion, transplantation, sexual activity, breastfeeding, respiratory droplet, and animal bite is discussed. Epidemic control requires adequate clearance of mosquito breeding grounds and personal protection against mosquito bite.
Download full publication:
- Details
In:
Nature
Author:
Erika Check Hayden
A protein that helps Zika virus infect adult skin cells might also give the virus access to stem cells that make brain cells, suggests a study carried out on donated human fetal tissue.
The result — published today in Cell Stem Cell 1 — is part of a growing body of research that seeks to determine how Zika might cause birth defects, but that requires a type of tissue that is increasingly controversial for researchers in the United States.
Recent advances in neuroscience and cell technology have given hints as to why some babies born to Zikainfected mothers have abnormally small heads — a condition called microcephaly — and other problems, such as eye damage. But to fully understand what is happening in the womb, some scientists say that they need to study tissue from fetuses, which can be donated by couples who terminate pregnancies.
Download full publication:
- Details
In:
Nature
Author:
Declan Butler
Before October 2015, the few scientists who knew much about the Zika virus could have summed it up in two words: mostly harmless.
That’s still largely true. The virus, which is mainly spread by the Aedes aegypti mosquito, causes no or very mild symptoms in most people who catch it. But last October, northeastern Brazil reported an abrupt rise in the number of babies born with an abnormally small head, a condition known as microcephaly. The timing roughly coincided with outbreaks of Zika months earlier, and since then scientists have been scrambling to find out just how harmful the virus might be to fetuses.
Download full publication: