In:

The New England Journal of Medicine

Authors:

P. Brasil, J.P. Pereira, Jr., M.E. Moreira, R.M. Ribeiro Nogueira, L. Damasceno, M. Wakimoto, R.S. Rabello, S.G. Valderramos, U.-A. Halai, T.S. Salles, A.A. Zin, D. Horovitz, P. Daltro, M. Boechat, C. Raja Gabaglia, P. Carvalho de Sequeira, J.H. Pilotto, R. Medialdea-Carrera, D. Cotrim da Cunha, L.M. Abreu de Carvalho, M. Pone, A. Machado Siqueira, G.A. Calvet, A.E. Rodrigues Baião, E.S. Neves, P.R. Nassar de Carvalho, R.H. Hasue, P.B. Marschik, C. Einspieler, C. Janzen, J.D. Cherry, A.M. Bispo de Filippis, and K. Nielsen-Saines

BACKGROUND
Zika virus (ZIKV) has been linked to central nervous system malformations in fetuses. To characterize the spectrum of ZIKV disease in pregnant women and infants, we followed patients in Rio de Janeiro to describe clinical manifestations in mothers and repercussions of acute ZIKV infection in infants.

METHODS
We enrolled pregnant women in whom a rash had developed within the previous 5 days and tested blood and urine specimens for ZIKV by reverse-transcriptase–polymerasechain-reaction assays. We followed women prospectively to obtain data on pregnancy and infant outcomes.

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