In:

Neglected Tropical Diseases

Authors:

Claire L. Donald , Benjamin Brennan , Stephanie L. Cumberworth , Veronica V. Rezelj, Jordan J. Clark, Marli T. Cordeiro, Rafael Freitas de Oliveira França, Lindomar J. Pena, Gavin S. Wilkie, Ana Da Silva Filipe, Christopher Davis, Joseph Hughes, Margus Varjak, Martin Selinger, Luíza Zuvanov, Ania M. Owsianka, Arvind H. Patel, John McLauchlan, Brett D. Lindenbach, Gamou Fall, Amadou A. Sall, Roman Biek, Jan Rehwinkel, Esther Schnettler, Alain Kohl

Abstract

Background

The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern. Little is currently known about the evolution and biology of ZIKV and the factors that contribute to the associated pathogenesis. Determining genomic sequences of clinical viral isolates and characterization of elements within these are an important prerequisite to advance our understanding of viral replicative processes and virus-host interactions.

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