Publicações do Grupo MERG
- Details
In:
Emerging Infectious Diseases journal
Authors:
Microcephaly Epidemic Research Group - Maria de Fátima P.M. Albuquerque, Thalia V.B. Araújo, Andreza Barkokebas, Luciana Caroline A. Bezerra, Cynthia Braga, Sinval P. Brandão-Filho, Carlos Alexandre A. Brito, Renata G. Cabral, Adriana R. Carneiro, Maria Durce C.G. Carvalho, Marli T. Cordeiro, Iran Costa-Jr, Adriana S.C. Cunha, Danielle D.C.S. Cruz, Rafael Dhalia, Adriano N. Hazin, Leticia Katz, Ernesto T.A. Marques, Celina Maria T. Martelli, Demócrito B. Miranda-Filho, Monica Maria C. Moraes, Cristina Mota, Vanessa V.D.L. Mota, Regina C.F. Ramos, Maria Angela W. Rocha, Paula Fabiana S. Silva, Wayner V. Souza, Ana Van Der Linden, Ricardo A.A. Ximenes (Recife, Brazil); Joanna d’Arc L. Batista (Chapeco, Brazil); Enrique Vazquez, Giovanini E. Coelho, Juan J. Cortez-Escalante, Elisete Duarte, Cláudio M.P. Henriques, Carlos Frederico C.A. Melo, Wanderson K. Oliveira (Brasilia, Brazil); Lavínia Schüler-Faccini (Porto Alegre, Brazil); Sylvain Aldighieri, Maria Almiron, Jairo Mendez-Rico, Pilar Ramon-Pardo (Washington, DC, USA); Laura C. Rodrigues (London, UK).
Abstract:
We studied the clinical characteristics for 104 infants born with microcephaly in the delivery hospitals of Pernambuco State, Brazil, during 2015. Testing is ongoing to exclude known infectious causes. However, microcephaly peaked in October and demonstrated central nervous system abnormalities with brain dysgenesis and intracranial calcifications consistent with an intrauterine infection.
Read more: http://wwwnc.cdc.gov/eid/article/22/6/16-0062_article
- Details
In:
American Journal of Public Health
Authors:
Demócrito de Barros Miranda-Filho, PhD, Celina Maria Turchi Martelli, PhD, Ricardo Arraes de Alencar Ximenes, PhD, Thalia Velho Barreto Araújo, PhD, Maria Angela Wanderley Rocha, MsC, Regina Coeli Ferreira Ramos, MsC, Rafael Dhalia, PhD, Rafael Freitas de Oliveira Franca, PhD, ̧ Ernesto Torres de Azevedo Marques Junior, PhD, and Laura Cunha Rodrigues, PhD ́.
Objectives:
To provide an initial description of the congenital syndrome presumably associated with infection by Zika virus compared with other syndromes including congenital infections of established etiologies.
Methods:
We provide an overview of a published case series of 35 cases, a clinical series of 104 cases, and published and unpublished reports of clinical and laboratory findings describing cases diagnosed since the beginning of the epidemic of microcephaly in Brazil.
Results:
About 60% to 70% of mothers report rash during pregnancy; mainly in the first trimester. Principal features are microcephaly, facial disproportionality, cutis girata, hypertonia/spasticity, hyperreflexia, and irritability; abnormal neuroimages include calcifications, ventriculomegaly, and lissencephaly. Hearing and visual abnormalities may be present.
Conclusions:
Preliminary data suggest that severe congenital abnormalities are linked to Zika virus infection. Cases have severe abnormalities, and although sharing many characteristics with congenital abnormalities associated with other viral infections, abnormalities presumably linked to the Zika virus may have distinguishing characteristics.
These severe neurologic abnormalities may result in marked mental retardation and motor disabilities for many surviving offspring. Policy Implications. Affected nations need to prepare to provide complex and costly multidisciplinary care that children diagnosed with this new congenital syndrome will require. (Am J Public Health. 2016;106:598–600. doi:10.2105/AJPH.2016.303115).
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